Myofibrils put the squeeze on nuclei

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2017 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 19, pages 1,148-1,150 (issn: 1465-7392, eissn: 1476-4679,

Copyright policy )Funded by:NIH | MOUSE GENETICS

Authors: Jonathan N, Rosen; Mary K, Baylies;

doi: 10.1038/ncb3618

pmid: 28960202

pmc: PMC5933531

Myofibrils put the squeeze on nuclei

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Abstract

During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils.

Related Organizations

Memorial Sloan Kettering Cancer Center
United States

Keywords

Cell Nucleus, Myofibrils, Movement, Humans, Muscle Contraction

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