When cancer needs what's non-essential

descriptionPublicationkeyboard_double_arrow_right Article 19 Apr 2017 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 19, pages 418-420 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Mark R, Sullivan; Matthew G, Vander Heiden;

doi: 10.1038/ncb3523

pmid: 28422952

When cancer needs what's non-essential

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Abstract

The non-essential amino acids serine and glycine are critical for proliferative metabolism. A study in Nature now finds that dietary serine and glycine deprivation inhibits growth of some tumours. Whether this dietary intervention is effective depends on both the oncogenic context and tumour tissue of origin.

Related Organizations

Harvard University
United States
Dana-Farber Cancer Institute
United States
Massachusetts Institute of Technology
United States

Keywords

Glycine, Mice, Neoplasms, Diet, Protein-Restricted, Serine, Animals, Humans, Energy Metabolism, Cell Proliferation

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