Directing lipid transport at membrane contact sites

descriptionPublicationkeyboard_double_arrow_right Article 27 Apr 2016 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 18, pages 461-463 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Michael, Krauβ; Volker, Haucke;

doi: 10.1038/ncb3345

pmid: 27117329

Directing lipid transport at membrane contact sites

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Abstract

Contact sites between the endoplasmic reticulum and the plasma membrane mediate receptor signalling. How this function is controlled physically and functionally is poorly understood. Extended synaptotagmins are now shown to shuttle the lipid metabolite diacylglycerol from the plasma membrane to the endoplasmic reticulum in receptor-stimulated cells.

Related Organizations

Leibniz Association
Germany
Leibniz Institute for Neurobiology
Germany
Freie Universität Berlin
Germany
Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Germany

Keywords

Synaptotagmins, Cell Membrane, Animals, Biological Transport, Endoplasmic Reticulum, Lipids

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