Cadherin adhesion controlled by cortical actin dynamics

Name: Cadherin adhesion controlled by cortical actin dynamics
Creator: Johan, de Rooij
Keywords: 2. Zero hunger, 0301 basic medicine, 03 medical and health sciences, Cell Adhesion, Animals, Adherens Junctions, Cadherins, Sarcoma 180, Mechanotransduction, Cellular, Actins

Johan, de Rooij

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Nature Cell Biologyarrow_drop_down

Nature Cell Biology

Article . 2014 . Peer-reviewed

License: Springer TDM

Data sources: Crossref

Nature Cell Biology

Article . 2014

Data sources: Europe PubMed Central

https://dx.doi.org/10.1038/ncb...

Article

Data sources: Microsoft Academic Graph

Cadherin adhesion controlled by cortical actin dynamics

descriptionPublicationkeyboard_double_arrow_right Article 30 May 2014 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 16, pages 508-510 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Johan, de Rooij;

doi: 10.1038/ncb2980

pmid: 24875740

Cadherin adhesion controlled by cortical actin dynamics

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Abstract

Cadherin-containing cell-cell junctions respond to intercellular tension by increasing their size, strength and complexity. The mechanical regulation of cadherin adhesions is now shown to involve myosin-dependent tension in the cortical actomyosin cytoskeleton. This reduces actin turnover to decrease the mobility of cadherin molecules and increase their concentration at junctions.

Related Organizations

Utrecht University
Netherlands
University Medical Center Utrecht
Netherlands
Center for Translational Molecular Medicine
Netherlands

Keywords

Cell Adhesion, Animals, Adherens Junctions, Cadherins, Sarcoma 180, Mechanotransduction, Cellular, Actins

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