In vitro Pharmacological Profile of 3-N-(2-Fluoroethyl)Spiperone
Copyright policy )In vitro Pharmacological Profile of 3-N-(2-Fluoroethyl)Spiperone
The binding affinities of spiperone and 3-N-(2-fluoroethyl)spiperone (FESP) have been compared for several rodent brain receptor sites and for inhibition of monoamine release and uptake sites. FESP and spiperone have almost identical profiles, namely a high affinity for dopamine-D2and serotonin-S2receptors, a low affinity for α1-adrenergic receptors, and negligible binding to other sites. These results suggest that available data on spiperone binding may be applied to the interpretation of PET data obtained with FESP.
- Janssen (Belgium) Belgium
- Université Catholique de Louvain Belgium
- Janssen Pharmaceutica Belgium
Chemical Phenomena, Receptors, Dopamine D2, Guinea Pigs, Brain, In Vitro Techniques, Rats, Receptors, Dopamine, Chemistry, Spiperone, Receptors, Serotonin, Animals
Chemical Phenomena, Receptors, Dopamine D2, Guinea Pigs, Brain, In Vitro Techniques, Rats, Receptors, Dopamine, Chemistry, Spiperone, Receptors, Serotonin, Animals
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