Screening inhibitors of anthrax lethal factor
Copyright policy )Screening inhibitors of anthrax lethal factor
The disease anthrax is caused by lethal factor, an enzyme component of the toxin produced by the spore-forming bacterium Bacillus anthracis. Here we describe substrate molecules for this factor that offer a means for high-throughput screening of potential inhibitors for use in anthrax treatment. Our assay should help to answer the urgent call for new and specific therapies to combat this pathogen after its recent emergence as a terrorist bioweapon.
- National Research Council Italy
- French National Centre for Scientific Research France
- Institut Pasteur France
- University of Padua Italy
Antigens, Bacterial, Macrophages, Bacterial Toxins, Drug Evaluation, Preclinical, Cell Line, Substrate Specificity, Anthrax, Bacillus anthracis, Humans, Mitogen-Activated Protein Kinases
Antigens, Bacterial, Macrophages, Bacterial Toxins, Drug Evaluation, Preclinical, Cell Line, Substrate Specificity, Anthrax, Bacillus anthracis, Humans, Mitogen-Activated Protein Kinases
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