Melanocortin receptors in leptin effects
Copyright policy )Melanocortin receptors in leptin effects
Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4. We now show that MC4 receptor signalling is an important mediator of leptin's effects on food intake and body weight, demonstrating a link between the two systems.
- University of Mary United States
- University System of Ohio United States
- Harborview Medical Center United States
- University of Cincinnati United States
- Roche (United States) United States
Leptin, Male, Receptors, Melanocortin, Body Weight, Glucagon-Like Peptides, Proteins, Anorexia, Rats, Eating, Receptors, Corticotropin, Animals, Melanocyte-Stimulating Hormones, Peptides, Proto-Oncogene Proteins c-fos, Paraventricular Hypothalamic Nucleus, Signal Transduction
Leptin, Male, Receptors, Melanocortin, Body Weight, Glucagon-Like Peptides, Proteins, Anorexia, Rats, Eating, Receptors, Corticotropin, Animals, Melanocyte-Stimulating Hormones, Peptides, Proto-Oncogene Proteins c-fos, Paraventricular Hypothalamic Nucleus, Signal Transduction
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