This study explores the dimensionality (factor analysis) and the relationships (empirical networks) between the Zuckerman alternative five-factor personality model and the two current pathological dimensional personality systems based on the International Classification of Diseases-11th Revision (ICD-11) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), Section III. To this end, the Zuckerman-Kuhlman-Aluja Personality Questionnaire-Short Form (ZKA-PQ/SF), the Personality Inventory for ICD-11, and the Personality Inventory for DSM-5-Short Form were used with 1,229 healthy community subjects: 578 men (Mage = 40.03, SD = 17.77) and 651 women (Mage = 39.63, SD = 17.81). The results show that the pathological traits of Negative Affectivity, Detachment, Disinhibition, and Antagonism/Dissociality are correlatively placed in the Neuroticism, Extraversion, Sensation Seeking, and Aggressiveness dimensional space. Psychoticism is positioned, to a lesser extent and with a similar loading, in Sensation Seeking and Neuroticism, whereas Anankastia is associated with the Activity factor. The five ZKA-PQ domains explain 42% of the variance of Personality Inventory for ICD-11 and 39% of the variance of Personality Inventory for DSM-5-Short Form, whereas the ZKA-PQ facets explain 47% and 44%, respectively. It is concluded that Zuckerman's alternative five-factor model of personality may be useful to better understand the position of pathological or maladaptive traits in the space of normal personality, complementarily to the five-factor model. It also helps to integrate the maladaptive personality traits of the ICD-11 and the DSM-5 Section III into a single system. (PsycInfo Database Record (c) 2021 APA, all rights reserved).