AbstractShallow slow slip events accompanied by seismicity has been increasingly reported in subduction zones during the last decade; however, the relationship between shallow slip events and seismicity is unclear. We report episodic slow slip events and seismicity at the southernmost Ryukyu Trench. The inversion results from GPS‐derived cumulative displacements indicate that the slow slip events occur offshore in northeastern Taiwan on the shallow subduction interface, where high seismic VP/VS ratios applies. Seismicity is observed above the subduction interface for locations of significant variations in the VP/VS ratio and does not follow the migration of peak slip along the subduction interface. We calculated the temporal evolution between the seismicity and the propagation of slow slip events and determined that seismicity is not primarily driven by slip propagation. The spatiotemporal relationship, coupled with the VP/VS ratio, suggests that high‐pressure fluid activity may be crucial to episodes of slow slip events and seismicity.