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</script>The standard variance components method for mapping quantitative trait loci is derived on the assumption of normality. Unsurprisingly, statistical tests based on this method do not perform so well if this assumption is not satisfied. We use the statistical concept of copulas to relax the assumption of normality and derive a test that can perform well under any distribution of the continuous trait. In particular, we discuss bivariate normal copulas in the context of sib-pair studies. Our approach is illustrated by a linkage analysis of lipoprotein(a) levels, whose distribution is highly skewed. We demonstrate that the asymptotic critical levels of the test can still be calculated using the interval mapping approach. The new method can be extended to more general pedigrees and multivariate phenotypes in a similar way as the original variance components method.
321011 Medical Genetics, normal distribution, Netherlands Twin Register (NTR), copulas, Quantitative Trait Loci, Normal Distribution, 730107 Inherited diseases (incl. gene therapy), genome scan, 310, C1, Twins, Dizygotic, Psychology, Humans, Copulas, Genetics & Heredity, Analysis of Variance, Likelihood Functions, Multidisciplinary, Models, Statistical, Quantitative Traits, Models, Genetic, Chromosome Mapping, Genome Scan, Phenotype, Variance Components, Sib-pair Analysis, Maps, quantitative trait loci, Linkage Analysis, variance components, Behavioral Sciences, quantitative trait loci ; variance components ; normal distribution ; copulas ; genome scan, Lipoprotein(a)
321011 Medical Genetics, normal distribution, Netherlands Twin Register (NTR), copulas, Quantitative Trait Loci, Normal Distribution, 730107 Inherited diseases (incl. gene therapy), genome scan, 310, C1, Twins, Dizygotic, Psychology, Humans, Copulas, Genetics & Heredity, Analysis of Variance, Likelihood Functions, Multidisciplinary, Models, Statistical, Quantitative Traits, Models, Genetic, Chromosome Mapping, Genome Scan, Phenotype, Variance Components, Sib-pair Analysis, Maps, quantitative trait loci, Linkage Analysis, variance components, Behavioral Sciences, quantitative trait loci ; variance components ; normal distribution ; copulas ; genome scan, Lipoprotein(a)
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