Synthesis of the C9−C23 (C9′−C23′) Fragment of the Dimeric Natural Product Rhizopodin

descriptionPublicationkeyboard_double_arrow_right Article 09 Apr 2010 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 12, pages 2,036-2,039 (issn: 1523-7060, eissn: 1523-7052,

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Authors: Zheng, Chen; Liankai, Song; Zhengshuang, Xu; Tao, Ye;

doi: 10.1021/ol100515m

pmid: 20380407

Synthesis of the C9−C23 (C9′−C23′) Fragment of the Dimeric Natural Product Rhizopodin

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Abstract

A stereoselective assembly of the C9-C23 (C9'-C23') fragment of rhizopodin, a 38-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles >50% of the carbon skeleton and the stereochemical elements present in the natural product.

Related Organizations

Shenzhen University
China (People's Republic of)
Hong Kong Polytechnic University
China (People's Republic of)
Peking University
China (People's Republic of)
University Town of Shenzhen
China (People's Republic of)

Keywords

Biological Products, Stereoisomerism, Macrolides, Dimerization, Oxazoles

18 Research products, page 1 of 2

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