Absolute Configuration of Amphidinin A

descriptionPublicationkeyboard_double_arrow_right Article 16 May 2014 English Publisher:American Chemical Society (ACS)Journal:Journal of Natural Products, volume 77, pages 1,541-1,544 (issn: 0163-3864, eissn: 1520-6025,

Copyright policy )

Authors: Takahiro, Iwai; Takaaki, Kubota; Jun'ichi, Kobayashi;

doi: 10.1021/np5003065

pmid: 24836179

Absolute Configuration of Amphidinin A

- Summary
- Subjects
- Metrics

Abstract

The absolute configurations at six stereogenic centers in amphidinin A (1), a cytotoxic linear polyketide isolated from a symbiotic marine dinoflagellate, Amphidinium sp., were elucidated to be 2R, 4R, 6S, 9R 11R, and 12S by the combination of J-based configuration analysis, modified Mosher's method, and density-functional theory calculations.

Related Organizations

Hokkaido University
Japan
Hokkaido Bunkyo University
Japan

Keywords

Molecular Structure, Polyketides, Dinoflagellida, Marine Biology, Stereoisomerism, Furans, Nuclear Magnetic Resonance, Biomolecular

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	21
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%