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Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes

descriptionPublicationkeyboard_double_arrow_right Article 07 Nov 2011Publisher:American Chemical Society (ACS)Journal:Nano Letters, volume 11, pages 5,391-5,395 (issn: 1530-6984, eissn: 1530-6992,

Authors: Daan Frenkel; Francisco J. Martinez-Veracoechea; Robert Vácha;

doi: 10.1021/nl2030213

pmid: 22047641

Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes

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Abstract

Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.

Related Organizations

University of Cambridge
United Kingdom
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Keywords

Cell Membrane, Nanoparticles, Molecular Dynamics Simulation, Particle Size, Models, Biological, Endocytosis

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