Pyrazolsulfonamide Agonists of Oxytocin Receptor
Copyright policy )Pyrazolsulfonamide Agonists of Oxytocin Receptor
Title: Pyrazolsulfonamide Agonists of Oxytocin Receptor Patent/Patent Application Number: WO 2014/111356 A1 Publication date: July 24, 2014 Priority Application: EP 2013-151632 Priority date: January 17, 2013 Inventors: Bissantz, C.; Grundschober, C.; Nettekoven, M.; Plancher, J.-M.; Vifian, W. Assignee Company: Hoffmann-La Roche, Inc. Disease Area: CNS Biological Target: Oxytocin receptor Summary: The present application discloses a series of pyrazolsulfonamides as agonists of the oxytocin receptor. Oxytocin is a nine amino acid cyclic peptide hormone; it is a potent uterotonic agent clinically used to induce labor. Oxytocin and its receptors exist in the nucleus accumbens and the hippocampus. Agonists of the oxytocin receptor are claimed as potential treatment for a variety of CNS diseases such as autism, schizophrenia, anxiety disorders, drug addiction, and Prader-Willi syndrome. Important Compound Classes:
- Drexel University United States
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