Publisher Summary This chapter focuses on plant products with hypocholesterolemic potentials. C. arietinum has been found to have highly significant hypocholesterolemicaction in rats and rabbits. The hypocholesterolemic property is detected in lipid extracts of the plant, as well as in the defatted portion, the former being more potent in this respect. Its lipid-lowering action could possibly be attributed to inhibition of the synthesis of cholesterol in the liver and increased catabolism and excretion of cholesterol end products in the feces. In patients fed a high-fat diet, the supplementation of C. arietinum has been reported to lower serum lipids significantly. The hypocholesterolemic effect has been found to be associated with a statistically significant increase in 24-h fecal excretion of total bile acids, without any significant increase in neutral sterols. From the reports on their potential effectiveness against hypercholesterolemia, it is assumed that the botanicals have a major role to play in the management of hyperlipidemia, which needs further exploration for necessary development of drugs and nutraceuticals from natural resources. However, many herbal remedies used today have not undergone careful scientific assessment and some have the potential to cause serious toxic effects and major drug-to-drug interactions. Continuing research is necessary to elucidate the pharmacological activities of the many herbal remedies now being used to treat hyperlipidemia, atherosclerosis, and other cardiovascular diseases.