Vitamin d3 and brain development
Copyright policy )Vitamin d3 and brain development
Evidence for the presence of the vitamin D receptor in brain implies this vitamin may have some function in this organ. This study investigates whether vitamin D(3) acts during brain development. We demonstrate that rats born to vitamin D(3)-deficient mothers had profound alterations in the brain at birth. The cortex was longer but not wider, the lateral ventricles were enlarged, the cortex was proportionally thinner and there was more cell proliferation throughout the brain. There were reductions in brain content of nerve growth factor and glial cell line-derived neurotrophic factor and reduced expression of p75(NTR), the low-affinity neurotrophin receptor. Our findings would suggest that low maternal vitamin D(3) has important ramifications for the developing brain.
- Griffith University Australia
- Park Centre for Mental Health Australia
- University of Queensland Australia
- French National Centre for Scientific Research France
- University of Queensland Australia
Male, Neurotrophic Factors, Targeted Ablation, Neurotrophic Factor, 320702 Central Nervous System, Pregnant-women, Mitosis, Down-Regulation, 1,25-dihydroxyvitamin D-3, Nervous System Malformations, Receptor, Nerve Growth Factor, Rats, Sprague-Dawley, C1, Pregnancy, 616, Nerve Growth Factor, D-deficient Rats, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Glial Cell Line-Derived Neurotrophic Factor, Nerve Growth Factors, Vitamin D, Nerve Growth-factor, Hypovitaminosis-d, Cognitive and computational psychology, 321021 Psychiatry, Cholecalciferol, Neurons, P75, 320700 Neurosciences, Neurosciences, Brain Development, Brain, 730211 Mental health, Cell Differentiation, Brain Morphology, 730104 Nervous system and disorders, Placental Insufficiency, Immunohistochemistry, Rats, C6.9 Glioma-cells, Messenger-rna, Animals, Newborn, Female, D-receptor, Cell Division
Male, Neurotrophic Factors, Targeted Ablation, Neurotrophic Factor, 320702 Central Nervous System, Pregnant-women, Mitosis, Down-Regulation, 1,25-dihydroxyvitamin D-3, Nervous System Malformations, Receptor, Nerve Growth Factor, Rats, Sprague-Dawley, C1, Pregnancy, 616, Nerve Growth Factor, D-deficient Rats, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Glial Cell Line-Derived Neurotrophic Factor, Nerve Growth Factors, Vitamin D, Nerve Growth-factor, Hypovitaminosis-d, Cognitive and computational psychology, 321021 Psychiatry, Cholecalciferol, Neurons, P75, 320700 Neurosciences, Neurosciences, Brain Development, Brain, 730211 Mental health, Cell Differentiation, Brain Morphology, 730104 Nervous system and disorders, Placental Insufficiency, Immunohistochemistry, Rats, C6.9 Glioma-cells, Messenger-rna, Animals, Newborn, Female, D-receptor, Cell Division
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