descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2018 English Publisher:Elsevier BVJournal:Trends in Genetics, volume 34, pages 167-170 (issn: 0168-9525,

Authors: Patricia Sieber; Matthias Platzer; Stefan Schuster;

doi: 10.1016/j.tig.2017.12.009

pmid: 29366605

The Definition of Open Reading Frame Revisited

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Abstract

The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.

Related Organizations

Leibniz Institute on Aging – Fritz Lipmann Institute
Germany
National Institute of Health
Pakistan
Friedrich Schiller University Jena
Germany
Leibniz Association
Germany

Keywords

Open Reading Frames, Eukaryotic Cells, Prokaryotic Cells, Codon, Terminator, Codon, Initiator, Computational Biology, DNA, Exons, 5' Untranslated Regions

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