Abstract Today's digital technologies, such as social media, business analytics, the Internet of Things, big data, advanced manufacturing, 3D printing, cloud and cyber-solutions and MOOCs, permeate every private and public organization. However, even if this phenomenon has been analyzed for entrepreneurship in general, to the best of our knowledge, the impact of digital technologies on academic entrepreneurship remains not only slightly addressed. With the aim of filling this gap, this paper proposes a novel contribution regarding the emerging concept of Digital Academic Entrepreneurship. Based on a qualitative literature review, an interpretative framework for Digital Academic Entrepreneurship is deductively proposed that is composed of the following components: the rationale for the adoption of digital technologies for academic entrepreneurship (why), the emerging forms of digital academic entrepreneurship (what), the stakeholders involved through the digital technologies to achieve the academic entrepreneurship goal (who), and the processes of academic entrepreneurship supported by digital technologies (how). The discussion section provides a conceptualization of Digital Academic Entrepreneurship. The paper closes with the identification of a research agenda for this promising and under-researched field.