Coordination of COPII vesicle trafficking by Sec23
Copyright policy )Coordination of COPII vesicle trafficking by Sec23
Coat protein complex II (COPII) is a multi-subunit protein complex responsible for the formation of membrane vesicles at the endoplasmic reticulum. The assembly of this complex on the endoplasmic reticulum membrane needs to be tightly regulated to ensure efficient and specific incorporation of cargo proteins into nascent vesicles. Recent studies of a genetic disease affecting COPII function, and a structural analysis of COPII subunit interactions emphasize the central role of the Sec23 subunit in COPII coat assembly. Similarly, the demonstration that Sec23 interacts physically and functionally with proteins involved in both vesicle tethering and the transport along microtubules indicates that the Sec23 subunit is crucially important in linking COPII vesicle formation to anterograde transport events.
- University of California, Berkeley United States
- University of Geneva Switzerland
- Howard Hughes Medical Institute United States
Saccharomyces cerevisiae Proteins, GTPase-Activating Proteins, Genetic Diseases, Inborn, Golgi Matrix Proteins, Membrane Proteins, Dynactin Complex, Fibroblasts, Microtubules, Models, Biological, Microscopy, Electron, Humans, COP-Coated Vesicles, Microtubule-Associated Proteins, Protein Processing, Post-Translational, Skin
Saccharomyces cerevisiae Proteins, GTPase-Activating Proteins, Genetic Diseases, Inborn, Golgi Matrix Proteins, Membrane Proteins, Dynactin Complex, Fibroblasts, Microtubules, Models, Biological, Microscopy, Electron, Humans, COP-Coated Vesicles, Microtubule-Associated Proteins, Protein Processing, Post-Translational, Skin
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