Forcing FAK into Transcriptional Activity

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2016 English Publisher:Elsevier BVJournal:Structure, volume 24, pages 1,223-1,225 (issn: 0969-2126,

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Authors: Daniel, Lietha;

doi: 10.1016/j.str.2016.07.004

pmid: 27486913

Forcing FAK into Transcriptional Activity

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Abstract

Focal adhesion kinase (FAK) has known signaling roles in cytoplasmic adhesion structures, but was recently shown to act as a transcriptional regulator in the nucleus. In this issue of Structure, Cardoso et al. (2016) report that mechanical forces translocate FAK to the nucleus of cardiomyocytes, and provide structural insights into how FAK interacts with the MEF2 transcription factor to control cardiac hypertrophy.

Related Organizations

Spanish National Cancer Research Centre
Spain

Keywords

Cell Nucleus, Focal Adhesion Protein-Tyrosine Kinases, Humans, Cardiomegaly, Protein-Tyrosine Kinases, Cells, Cultured, Signal Transduction

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