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Article . 2007 . Peer-reviewed
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Article . 2007
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The Dynamics of Signal Triggering in a gp130-Receptor Complex

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2007 United Kingdom English Publisher:Elsevier BVJournal:Structure, volume 15, pages 441-448 (issn: 0969-2126, Copyright policy )Funded by:WT | unidentified
Authors: Matadeen, R; Hon, W; Heath, J; Jones, E; Fuller, S;

doi: 10.1016/j.str.2007.02.006

pmid: 17437716

pmc: PMC1885967

The Dynamics of Signal Triggering in a gp130-Receptor Complex

Abstract

gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.

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United Kingdom
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Keywords

Cryoelectron Microscopy, Interleukin-11, Article, Mice, SIGNALING, Structural Biology, Cytokine Receptor gp130, Animals, Receptors, Interleukin-11, MOLIMMUNO, Molecular Biology, Protein Binding, Signal Transduction

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 70
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
70
Top 10%
Top 10%
Top 10%
Green
hybrid
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