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Open Chromatin and Hypertranscription in Embryonic Stem Cells

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2008 English Publisher:Elsevier BVJournal:Cell Stem Cell, volume 2, pages 408-410 (issn: 1934-5909, Copyright policy )
Authors: Turner, Bryan M.;

doi: 10.1016/j.stem.2008.04.006

pmid: 18462689

Open Chromatin and Hypertranscription in Embryonic Stem Cells

Abstract

In this issue of Cell Stem Cell, Efroni et al. (2008) use tiling microarrays to reveal genome-wide hypertranscription in mouse embryonic stem cells (ESCs), including expression of normally silent, noncoding regions. Hypertranscription may reflect the unusual "open" structure of ESC chromatin.

Related Organizations
Keywords

Transcriptional Activation, Transcription, Genetic, Gene Expression Profiling, Cell Differentiation, Cell Biology, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Mice, Genetics, Molecular Medicine, Animals, Humans, DNA, Intergenic, Embryonic Stem Cells

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 20
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Top 10%
Average
Top 10%
hybrid