Abstract Growing demand for air conditioning in recent years has caused a significant increase in demand for primary energy resources. Solar-powered cooling is one of the environmentally-friendly techniques which may help alleviate the problem. A promising solar cooling method is through the use of a liquid desiccant system, where humidity is absorbed directly from the process air by direct contact with the desiccant. The desiccant is then regenerated, again in direct contact with an external air stream, by solar heat at relatively low temperatures. The liquid desiccant system has many potential advantages over other solar air conditioning systems and can provide a promising alternative to absorption or to solid desiccant systems. Earlier work by the authors included theoretical simulations and preliminary experiments on the key components of the liquid desiccant system. The objective of the present study has been to construct a prototype system based on the knowledge gained, to monitor its performance, identify problems and carry out preliminary design optimization. A 16 kWt system was installed at the Energy Engineering Center at the Technion, in the Mediterranean city of Haifa. The system comprises a dehumidifier and a regenerator with their associated components operating together to dehumidify the fresh (ambient) air supply to a group of offices on the top floor of the building. LiCl-water is employed as the working fluid. The system is coupled to a solar collector field and employs two methods of storage – hot water and desiccant solution in the regenerated state. The performance of the system was monitored for five summer months under varying operating conditions. The paper describes the operation of the experimental system and presents the measured data and the calculated performance parameters.