The receptor activity modifying protein family of G protein coupled receptor accessory proteins
Copyright policy )The receptor activity modifying protein family of G protein coupled receptor accessory proteins
Receptor diversity for the calcitonin peptide family is created by the interaction of two 7-transmembrane proteins--the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CL-R)--with the receptor activity modifying protein (RAMP) family. The discovery of heterodimeric complexes of these proteins heralded a new era in the study of G protein coupled receptors (GPCRs), whereby receptor phenotype is no longer governed by just the GPCR. In this article, recent advances in the study of RAMPs are discussed--from our current understanding of the molecular basis of RAMP-receptor interaction to a broader role for RAMPs outside the calcitonin receptor family.
- University of Auckland New Zealand
- University of Melbourne Australia
Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Animals, Humans, Membrane Proteins, Amino Acid Sequence, Receptors, Calcitonin, Receptor Activity-Modifying Proteins, Protein Binding, Receptors, G-Protein-Coupled
Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Animals, Humans, Membrane Proteins, Amino Acid Sequence, Receptors, Calcitonin, Receptor Activity-Modifying Proteins, Protein Binding, Receptors, G-Protein-Coupled
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