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Childhood Absence Epilepsy evolving to Eyelid Myoclonia with Absence Epilepsy

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2018 Italy English Publisher:Elsevier BVJournal:Seizure, volume 61, pages 1-3 (issn: 1059-1311,

Authors: Galli, Jessica; Micheletti, Serena; Malerba, Laura; Fazzi, Elisa; Giordano, Lucio;

doi: 10.1016/j.seizure.2018.07.009

pmid: 30029089

handle: 11379/511174

Childhood Absence Epilepsy evolving to Eyelid Myoclonia with Absence Epilepsy

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Abstract

Children with Childhood Absence Epilepsy (CAE) may develop generalized tonic-clonic seizure or juvenile myoclonic epilepsy. A possible evolution to Eyelid Myoclonia with Absence Epilepsy (EMA) hasn't been documented yet. We report the electroclinical features of a case series of children with CAE that evolved to EMA after therapy withdrawal.Of 108 patients with CAE referred at our Epilepsy Center in the last ten years, 5 satisfied the inclusion criteria: CAE diagnosis, a minimum of 3 years follow-up, a progression to EMA after therapy withdrawal.All the six subjects were females. CAE was characterized by typical absences induced by hyperventilation; intermittent photic stimulation (IPS) was negative. All subjects were treated successfully with valproate. After drug withdrawal, all the six girls presented EMA. EMA was characterized by eyelid myoclonia with or without brief absences related to generalized spike/polyspike-waves discharges induced by IPS and less frequently by eye-closure.Our study documented another possible evolution of CAE into EMA. These results support the hypothesis that these two epileptic conditions are dynamic processes evolving into one another. CAE and EMA could be considered "system epilepsy" characterized by a high susceptibility to changes in the brain networks during specific life periods such as childhood and puberty.

Country

Italy

Related Organizations

University of Brescia
Italy

Keywords

Male, Adolescent, Valproic Acid, Myoclonic Epilepsy, Juvenile, Electroencephalography, Neurology; Neurology (clinical), Magnetic Resonance Imaging, Epilepsy, Absence, Child, Preschool, Disease Progression, Humans, Anticonvulsants, Female, Longitudinal Studies, Child, Retrospective Studies

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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%