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Revista Portuguesa de Cardiologia
Article . 2014 . Peer-reviewed
License: CC BY NC ND
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Revista Portuguesa de Cardiologia
Article
License: CC BY NC ND
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Revista Portuguesa de Cardiologia
Article . 2014
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Síndromes coronárias agudas sem supradesnivelamento‐ST nos octogenários: aplicabilidade dos scores GRACE e CRUSADE

Authors: Ana Faustino; Paula Mota; Joana Silva;

Síndromes coronárias agudas sem supradesnivelamento‐ST nos octogenários: aplicabilidade dos scores GRACE e CRUSADE

Abstract

Resumo: Introdução: A avaliação do risco isquémico e hemorrágico é fundamental na abordagem dos idosos com síndromes coronárias agudas, mas tem sido pouco estudada. Objetivo: Este estudo pretende avaliar a adequação dos scores GRACE e CRUSADE a doentes com síndrome coronária aguda sem supradesnivelamento‐ST e idade ≥ 80 anos, e identificar os principais preditores de mortalidade intra‐hospitalar e hemorragia major nesta população. Métodos: Foram avaliados 544 doentes com idade ≥ 80 anos com síndrome coronária aguda sem supradesnivelamento‐ST, incluídos no Registo Português de Síndromes Coronárias Agudas. Foram identificados os preditores de mortalidade intra‐hospitalar e de hemorragia major durante o internamento. Criaram‐se modelos preditores destes endpoints, posteriormente comparados com os scores GRACE e CRUSADE, e avaliada a sua adequação à população em estudo. Resultados: A realização de coronariografia associou‐se a redução do risco de mortalidade intra‐hospitalar e não se associou a aumento do risco de hemorragia major (OR 0,2, IC 95% 0,006‐0,49, p = 0,001). A hemorragia major foi preditora independente de mortalidade intra‐hospitalar (OR 10,9, IC 95% 2,36‐50,74, p = 0,002), e associou‐se a comorbilidades e à terapêutica farmacológica instituída. O score GRACE apresentou boa acuidade diagnóstica para mortalidade intra‐hospitalar (AUC 0,75, IC 95% 0,63‐0,87, p < 0,001), mas o CRUSADE mostrou fraca capacidade discriminatória de hemorragia major (AUC 0,51, IC 95% 0,30‐0,63, p = 0,942), contrariamente ao modelo preditor (AUC 0,68, IC 95% 0,52‐0,84, p = 0,032). Conclusões: O score GRACE é adequado para avaliação de risco nos octogenários, mas o CRUSADE é desajustado, sendo necessários novos scores para a avaliação de risco hemorrágico nesta faixa etária. Abstract: Introduction: Assessment of ischemic and bleeding risk is critical for the management of elderly patients with acute coronary syndromes, but it has been little studied. Objective: This study aims to assess the applicability of the GRACE and CRUSADE scores in patients aged ≥80 years with non‐ST‐elevation acute coronary syndrome (NSTE‐ACS), and to identify the main predictors of in‐hospital mortality and major bleeding in this population. Methods: We analyzed 544 patients aged ≥80 years with NSTE‐ACS included in the Portuguese Registry on Acute Coronary Syndromes and identified the predictors of in‐hospital mortality and major bleeding during hospitalization. Prediction models were created for these endpoints, then compared with the GRACE and CRUSADE scores, and their applicability to the study population was assessed. Results: Use of coronary angiography was associated with reduced risk of in‐hospital mortality, without increasing risk of major bleeding (OR 0.2, 95% CI 0.006‐0.49, p=0.001). Major bleeding was an independent predictor of in‐hospital mortality (OR 10.9, 95% CI 2.36‐50.74, p=0.002), and was associated with comorbidities and pharmacological therapy during hospitalization. The GRACE score showed good diagnostic accuracy for in‐hospital mortality (AUC 0.75, 95% CI 0.63‐0.87, p<0.001), but the CRUSADE score had weak discriminatory capacity for major bleeding (AUC 0.51, 95% CI 0.30‐0.63, p=0.942), unlike our prediction model (AUC 0.68, 95% CI 0.52–0.84, p=0032). Conclusions: The GRACE score is suitable for risk assessment in octogenarians with NSTE‐ACS, but the CRUSADE score is inadequate, and new scores are required to assess bleeding risk in this age‐group. Palavras‐chave: Hemorragia, Intervenção, Mortalidade, Octogenários, Prognóstico intra‐hospitalar, Síndromes coronárias agudas, Keywords: Bleeding, Intervention, Mortality, Octogenarian patients, In‐hospital prognosis, Acute coronary syndromes

Related Organizations
Keywords

RC666-701, Diseases of the circulatory (Cardiovascular) system

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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
18
Average
Top 10%
Top 10%
gold