When using conventional methods, centric occlusion (CO) can be determined on conventional gypsum casts that are mounted in an analog articulator at centric relation (CR). In the digital environment, intraoral scanners (IOSs) can be used to record maxillary and mandibular scans articulated in CR. However, a digital protocol to locate the CO on articulated intraoral digital scans at CR by using computer-aided design (CAD) programs is needed. The present manuscript describes a straightforward technique to record CR by combining an IOS and a Kois deprogrammer. Afterwards, the acquired digital data are imported into a CAD program to locate CO. The technique includes a complete digital protocol to locate CO by using 3 different CAD programs: open-access non-dental, open-access dental, and dental CAD program.