Aspidospermatan–aspidospermatan and eburnane-sarpagine bisindole alkaloids from Leuconotis

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2010 Malaysia English Publisher:Elsevier BVJournal:Phytochemistry, volume 71, pages 1,365-1,370 (issn: 0031-9422,

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Authors: Gan, Chew Yan; Low, Yun Yee; Robinson, W.T.; Komiyama, K.; Kam, Toh Seok;

doi: 10.1016/j.phytochem.2010.05.015

pmid: 20542302

Aspidospermatan–aspidospermatan and eburnane-sarpagine bisindole alkaloids from Leuconotis

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Abstract

Leucofoline and leuconoline, representing the first members of the aspidospermatan-aspidospermatan and eburnane-sarpagine subclasses of the bisindole alkaloids, respectively, were isolated from the Malayan Leuconotis griffithii. The structures of these bisindole alkaloids were established using NMR and MS analysis, and in the case of leuconoline, confirmed by X-ray diffraction analysis. Both alkaloids showed weak cytotoxicity towards human KB cells.

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Malaysia

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Keywords

Plants, Medicinal, Molecular Structure, Molecular Conformation, Q Science (General), Stereoisomerism, QD Chemistry, Crystallography, X-Ray, Antineoplastic Agents, Phytogenic, KB Cells, Indole Alkaloids, Apocynaceae, Humans, Drug Screening Assays, Antitumor, Nuclear Magnetic Resonance, Biomolecular

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