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Other literature type . 2010
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Phytochemistry
Article . 2010 . Peer-reviewed
License: Elsevier TDM
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HAL Sorbonne Université
Article . 2010
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https://pubmed.ncbi.nlm.nih.go...
Article . 2010
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Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae)

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jun 2010 France English Publisher:Elsevier BVJournal:Phytochemistry, volume 71, pages 964-974 (issn: 0031-9422, Copyright policy )
Authors: Marti, G.; Eparvier, V.; Moretti, Christian; Prado, S.; Grellier, P.; Hue, N.; Thoison, O.; +3 Authors

doi: 10.1016/j.phytochem.2010.03.008

pmid: 20356612

Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae)

Abstract

In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 microg/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 microM. A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation.

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France
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Keywords

Plasmodium falciparum, Drug Resistance, Plant Roots, Antiplasmodial, Antimalarials, Benzophenones, Benzophenone, Parasitic Sensitivity Tests, 615, Clusiaceae, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Humans, Nuclear Magnetic Resonance, Biomolecular, Molecular Structure, Symphonia globulifera, LCESI-MS, Chloroquine, Fibroblasts, 540, LC/ESI-MS, French Guiana, Symphonone, Plant Bark

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
51
Top 10%
Top 10%
Top 10%
Green