Abstract Recently, a silicon photomultiplier (SiPM) became one of the strongest candidates for application in PET–MR or SPECT–MR dual-modality scanners. However, optimization of the scintillation detectors with SiPM light readout requires different approach than in the case of classic photomultipliers. The finite number of micro-cells in a SiPM creates nonlinear response for high number of incident photons. Moreover, the size and total number of micro-cells defines fill factor, which in turn affects the photon detection efficiency (PDE). Response of SiPMs is also highly sensitive to bias voltage causing changes in PDE and excess noise factor (ENF). Finally, each cell posses an effective dead time needed to fully recharge that cell after the photon detection. In this work the listed above unique features of SiPMs are overviewed. The reported data also contain measurements of energy resolution and 22 Na time resolution.