Impact of the matrix metalloproteinase MMP-3 on dementia

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2007 English Publisher:Elsevier BVJournal:Neurobiology of Aging, volume 28, pages 1,215-1,220 (issn: 0197-4580,

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Authors: Nicole, Helbecque; Dominique, Cottel; Xavier, Hermant; Philippe, Amouyel;

doi: 10.1016/j.neurobiolaging.2006.05.030

pmid: 16822591

Impact of the matrix metalloproteinase MMP-3 on dementia

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Abstract

Cerebral accumulation of beta-amyloid peptide (Abeta) is a central event in the pathogenesis of Alzheimer's disease (AD). Several proteases were shown to hydrolyze Abeta in vitro or in cell-based assays, and are likely candidates for a role in Abeta clearance in brain. Previous reports suggest that matrix metalloproteinases (MMPs) could be involved in such a mechanism. A functional polymorphism at position -1171 (5A/6A) in MMP-3 was examined in two independent studies to investigate the impact of this polymorphism on the risk of developing dementia. We found that subjects APOE epsilon4 non-carriers and 6A/6A homozygous for the MMP-3 polymorphism were at increased risk of dementia. Our findings support the hypothesis that MMPs may influence the risk of dementia.

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Keywords

Aged, 80 and over, Male, Risk, Polymorphism, Genetic, Apolipoprotein E4, DNA Mutational Analysis, Gene Frequency, Alzheimer Disease, Humans, Dementia, Female, Matrix Metalloproteinase 3, Alleles, Aged, Retrospective Studies

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