Abstract The purpose of the study was to explore serum pancreatic lipase activity and the serum lipid profile in relation to peripheral blood dendritic cell subsets and disease severity in males with psoriasis. Material and methods The study population consisted of 22 normolipidemic males with psoriasis and 12 aged-matched and body mass index (BMI)-matched healthy males. The percentages of peripheral blood dendritic cell (DC) subsets were evaluated using appropriate monoclonal antibodies and flow cytometry. The serum pancreatic lipase activity and the lipid profile were determined using standard enzymatic and colorimetric techniques. Results Pancreatic lipase activity was increased ( p = 0.56421), high-density lipoprotein (HDL)-cholesterol concentration ( p = 0.00584) was significantly decreased, triglyceride ( p = 0.00766) and VLDL-cholesterol ( p = 0.00765) levels were significantly increased in serum of psoriatic patients compared to controls. The serum pancreatic lipase activity showed significant correlation with serum triglyceride ( r = 0.42; p = 0.04721) and serum VLDL-cholesterol levels ( r = 0.42; p = 0.04721) in psoriatic individuals. In psoriatic patients the percentage of myeloid DCs was increased ( p = 0.54932), the percentage of lymphoid DCs was decreased ( p = 0.14210) and myeloid DC/lymphoid DC ratio was significantly increased ( p = 0.03569) compared to healthy individuals. Conclusion The direct cause of the abnormal lipid profile in psoriasis and its relationship with the immune system disturbances remains unclear. The reciprocal relationship between serum pancreatic activity and serum triglyceride level appears to confirm the hypothesis about abnormal lipid metabolism in psoriasis.