Abstract As integrated circuits scale down into nanometer dimensions, a great reduction on the reliability of combinational blocks is expected. This way, the susceptibility of circuits to intermittent and transient faults is becoming a key parameter in the evaluation of logic circuits, and fast and accurate ways of reliability analysis must be developed. This paper presents a reliability analysis methodology based on signal probability, which is of straightforward application and can be easily integrated in the design flow. The proposed methodology computes circuit’s signal reliability as a function of its logical masking capabilities, concerning multiple simultaneous faults occurrence.