Single electron tunneling circuits seem to be promising candidates as basic circuit elements of the next generation ultra-dense VLSI and ULSI circuits for their ultra-low power consumption, ultra-small size, and rich functionality. In this paper, design and simulation of novel configurable logic cells (CLCs) using single electron tunneling (SET) technology based threshold logic gate (TLG) are presented. The proposed CLC can realize all Boolean logic functions by configuring the control bits without changing the structure of the circuit and the parameters of TLG-SET based design. The logic operation of the circuit is simulated using Monte Carlo simulation. According to the simulation results, the circuit operation based on the transfer of single electrons between adjacent islands is stable.