The control of food intake and energy metabolism depends on the complex interaction between energy homeostasis, hedonic control of feeding, and environmental cues. Experimental research in animal models and also the clinical observation of patients with feeding disorders have led to an increased knowledge of the mechanisms that regulate appetite. The hypothalamus is the key component of this network. Hypothalamic nuclei send to and receive signals from the insula, orbitofrontal cortex, nucleus accumbens, dopaminergic reward system, and multiple chemical signals, including peptides and gastrointestinal hormones, to regulate feeding behavior. Recent studies have provided insight into the complex interactions between the homeostatic and hedonic control of feeding behavior, sharing some neurobiological mechanisms with addictions. Identification of potential therapeutic targets will allow the development of useful drugs to treat feeding behavior disorders, such as obesity.