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Mathematical Biosciences
Article . 2007 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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zbMATH Open
Article . 2007
Data sources: zbMATH Open
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Aging: Damage accumulation versus increasing mortality rate

Authors: Maxim S. Finkelstein;

Aging: Damage accumulation versus increasing mortality rate

Abstract

If aging is understood as some process of damage accumulation, it does not necessarily lead to increasing mortality rate. Within the framework of a suggested generalization of the Strehler-Mildwan (1960) [B.L. Strehler, A.S. Mildvan (1960). General theory of mortality and aging, Science, 132, 14] model, we show that even for models with monotonically increasing degradation, the mortality rate can still decrease. The decline in vitality and functions, as manifestation of aging, is modeled by the monotonically decreasing quality of life function. Using this function, the initial lifetime random variable with ultimately decreasing mortality rate is 'weighted' to result in a new random variable, which is already characterized by the increasing mortality rate.

Keywords

Aging, aging, Physiological, cellular and medical topics, quality of life function, accumulated damage, mortality, Models, Biological, Population dynamics (general), random vitality model, Life Expectancy, Quality of Life, Humans, Mortality, Signal detection and filtering (aspects of stochastic processes), jel: jel:Z0, jel: jel:J1

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Average
Top 10%
Average
bronze