Abstract Flexible electronics has extensively drawn attention in an extremely wide range of areas due to its unique advantages like portability, biocompatibility, wearability, and superior mechanical stability. Recently, microfluidic technology has been considered as an effective tool to fabricate flexible electronics because of its precise control and manipulation of fluids in microchannels. In this review, we provide a comprehensive and in-depth insight into flexible electronics from microfluidic technology, covering the basic elements as well as microfluidic fabrication of flexible electronics and various applications in biomedical engineering. Furthermore, an outlook for the future challenges and perspectives of the flexible electronics is proposed.