A model for the interaction of two chemicals
Copyright policy )A model for the interaction of two chemicals
We describe a method for studying the interaction of two anesthetic agents, Morphine and Midazolam, acting simultaneously in the same individual. Representing the levels of the two chemicals by diffusion processes, we assume their interaction is governed by a linear combination of the separate components. Pharmacological data is used to estimate the model parameters and, in particular, to determine the coefficient in the linear combination. This leads to the conclusion that the two chemicals have a counteractive effect.
- University of North Florida United States
Stochastic Processes, Morphine, Midazolam, stochastic differential equation, Models, Biological, Stochastic ordinary differential equations (aspects of stochastic analysis), Wiener process, Diffusion, Models, Chemical, Humans, Drug Interactions, pharmacology, Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.), Anesthetics
Stochastic Processes, Morphine, Midazolam, stochastic differential equation, Models, Biological, Stochastic ordinary differential equations (aspects of stochastic analysis), Wiener process, Diffusion, Models, Chemical, Humans, Drug Interactions, pharmacology, Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.), Anesthetics
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