Abstract In the Eastern Cordillera of Colombia, a new structural model constrained by field data, paleontologic determinations, and interpretations of seismic reflection profiles is proposed. The model implies 70 km of shortening, including reactivation of basement structures as inverse faults in both flanks of the chain. These faults propagated within the lower Cretaceous strata, inducing passively rooted and transported thrust sheets as the successive basement faults were reactivated. Two structural styles are identified in the western flank: (1) positive flower structures in a transpressive regime, which affected rocks older than upper Paleocene and were unconformably covered by post–late Paleocene sediments, and (2) compressive structures during the late Miocene–Recent Andean phase. Presently, WNW-ESE compression reactivates Late Paleocene structures, which locally affect Andean trends. In the western margin of the Eastern Cordillera, the Cambao thrust takes up most displacement, whereas the Bituima fault takes only a minor part. To the south, this relationship reverses, suggesting complementary behavior by the Bituima and Cambao faults, as well as a transfer zone. This suggestion explains the southward termination of the Guaduas syncline as a structure related to the Cambao fault, whereas the Bituima fault increases its displacement southward, generating the Girardot foldbelt that takes over the structural position of the Guaduas syncline.