While the concepts of remanufacturing and reverse logistics are gaining global popularity, the available literature and theory on strategic decision-making in these areas is limited. A remanufacturing decision-making framework (RDMF) was developed based upon extensive literature review, case studies with representatives of OE supplier companies, and was validated especially, for the automotive industry. The reman research targeted the following macro-level parameters: strategic product planning, design for reman, plant location, production systems, physical distribution, and cooperation among reman stakeholders. The strategic reman factors identified from the literature review were broadened by case studies and surveys to develop the RDMF. The findings served as the foundation for further research with automotive industry companies engaged in Original Equipment (OE) sales, Original Equipment Services (OES), and Independent Aftermarket (IAM) business. The research findings were validated by an industry survey of senior managers/executives and academic experts with significant experience in reman decision-making. Participants were asked to make paired comparisons using the Analytic Hierarchy Process (AHP), which helped the researchers to further refine and prioritize the strategic decision-making factors, thereby, strengthening the RDMF. The resultant RDMF is presented with implications for its usage in automotive reman processes. RDMF is also applicable for similar decision-making processes in other industrial sectors.