The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics
Copyright policy )The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics
The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy against COVID-19.
- University of Queensland Australia
- University of Queensland Australia
- University of Queensland Australia
- Indian Institute of Technology Kanpur India
Immunology, Pneumonia, Viral, Complement C5a, GPCRs, drug discovery, Receptors, G-Protein-Coupled, Betacoronavirus, Immunology and Allergy, Animals, Humans, Spotlight, Pandemics, Receptor, Anaphylatoxin C5a, complement system, 2403 Immunology, SARS-CoV-2, Antibodies, Monoclonal, COVID-19, Disease Models, Animal, 2723 Immunology and Allergy, cellular signaling, Coronavirus Infections, Signal Transduction
Immunology, Pneumonia, Viral, Complement C5a, GPCRs, drug discovery, Receptors, G-Protein-Coupled, Betacoronavirus, Immunology and Allergy, Animals, Humans, Spotlight, Pandemics, Receptor, Anaphylatoxin C5a, complement system, 2403 Immunology, SARS-CoV-2, Antibodies, Monoclonal, COVID-19, Disease Models, Animal, 2723 Immunology and Allergy, cellular signaling, Coronavirus Infections, Signal Transduction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).45 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!