Pyroptosis: Caspase-11 Unlocks the Gates of Death

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2015 English Publisher:Elsevier BVJournal:Immunity, volume 43, pages 835-837 (issn: 1074-7613,

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Authors: de Gassart A; Martinon F;

doi: 10.1016/j.immuni.2015.10.024

pmid: 26588774

Pyroptosis: Caspase-11 Unlocks the Gates of Death

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Abstract

How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.

Related Organizations

University of Lausanne
Switzerland

Keywords

caspase-11, Immunology, Nerve Tissue Proteins, Shock, Septic, Connexins, Infectious Diseases, danger signals, inflammation, Caspases, Pyroptosis, Immunology and Allergy, Animals, Humans, Receptors, Purinergic P2X7

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