In the present paper, the suitability of hydrate slurries in secondary refrigeration was investigated by the means of a new hydrate solid-fraction model. Considering the high melting enthalpy of CO2-containing hydrates, slurries presenting high hydrate solid fractions can carry sufficient latent heat to be useful for a two-phase secondary-refrigerant application. The model presented in this paper allowed to calculate the solid fraction of CO2 and CO2eTHF hydrate from thermodynamic conditions of pressure and temperature. Contrary to a previous work on single CO2 hydrates in a closed system, the present model can take into account hydrate mixture and is well adapted to additional CO2 injections (opened system). By relying on the hydrateconversion model results, the study of hydrates in suspension in a carrying liquid was also studied in an experimental loop and was based on a formation process by CO2 injection in a cooled aqueous solution.