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Heritability of endometriosis

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2015 English Publisher:Elsevier BVJournal:Fertility and Sterility, volume 104, pages 947-952 (issn: 0015-0282,

Authors: Pia Svedberg; Matts Olovsson; Ralf Kuja-Halkola; Rama Saha; Per Tornvall; Lena Marions; Hans Pettersson; +1 Authors

doi: 10.1016/j.fertnstert.2015.06.035

pmid: 26209831

Heritability of endometriosis

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Abstract

To estimate the relative contribution of genetic influences and prevalence on endometriosis.Analysis of self-reported data from a nationwide population-based twin registry.Not applicable.A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998-2002 or 2005-2006).None.Self-reported endometriosis, validated by medical records.A history of endometriosis was reported by 1,228 female twins. The probandwise concordance was 0.21 for MZ and 0.10 for DZ twins. Higher within-pair (tetrachoric) correlation was observed among MZ (0.47) compared with DZ (0.20) twins. The best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to unique environmental effects.Our findings suggest both genetic and unique (nonshared) environmental influences on the complex etiology of endometriosis and support the hypothesis that genes have a strong influence on phenotypic manifestations of endometriosis.

Related Organizations

Karolinska Institute
Sweden
Uppsala University
Sweden

Keywords

Adult, Models, Genetic, Endometriosis, Twins, Monozygotic, Middle Aged, Young Adult, Cross-Sectional Studies, Quantitative Trait, Heritable, Diseases in Twins, Twins, Dizygotic, Humans, Female, Genetic Predisposition to Disease, Aged

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