CD44 Orchestrates Metastatic Teamwork

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2018 English Publisher:Elsevier BVJournal:Developmental Cell, volume 47, pages 691-693 (issn: 1534-5807,

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Authors: Christine L, Chaffer; Jacky G, Goetz;

doi: 10.1016/j.devcel.2018.11.038

pmid: 30562512

CD44 Orchestrates Metastatic Teamwork

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Abstract

Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential.

Related Organizations

French Institute of Health and Medical Research
France
University of Strasbourg
France
Garvan Institute of Medical Research
Australia
UNSW Sydney
Australia
University of Strasbourg
France

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Keywords

Hyaluronan Receptors, Neoplastic Stem Cells, Humans, Breast Neoplasms, Cell Aggregation

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