Mitotic Mysteries: The Case of HP1

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2016 English Publisher:Elsevier BVJournal:Developmental Cell, volume 36, pages 477-478 (issn: 1534-5807,

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Authors: Higgins, Jonathan M.G.; Prendergast, Lisa;

doi: 10.1016/j.devcel.2016.02.019

pmid: 26954539

Mitotic Mysteries: The Case of HP1

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Abstract

The role of Heterochromatin Protein-1 (HP1) during mitosis has been controversial. Two recent studies in Science and Developmental Cell, from Tanno et al. (2015) and Abe et al. (2016), suggest that the means of HP1 localization and its function at inner centromeres are altered in cancer cells with chromosomal instability.

Related Organizations

Newcastle University
United Kingdom

Keywords

Carcinogenesis, Chromosomal Instability, Chromosome Segregation, Centromere, Humans, Cell Cycle Proteins, Developmental Biology

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