Gene Regulation: Activation through Space

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2016 English Publisher:Elsevier BVJournal:Current Biology, volume 26, pages R895-R898 (issn: 0960-9822,

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Authors: Felix, Muerdter; Alexander, Stark;

doi: 10.1016/j.cub.2016.08.031

pmid: 27728794

Gene Regulation: Activation through Space

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Abstract

A recent study visualizes nascent RNAs in live Drosophila embryos to establish a connection between enhancer strength and the frequency of transcriptional bursts. Interestingly, one enhancer can simultaneously activate two core promoters, challenging models of enhancer-core-promoter communication via direct protein-protein contacts.

Related Organizations

Vienna Biocenter
Austria
Research Institute of Molecular Pathology
Austria

Keywords

Transcriptional Activation, Enhancer Elements, Genetic, Gene Expression Regulation, Animals, Drosophila Proteins, Drosophila, Promoter Regions, Genetic

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