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Neuroanatomical Assessment of Biological Maturity

Authors: Brown, Timothy T.; Kuperman, Joshua M.; Chung, Yoonho; Erhart, Matthew; McCabe, Connor; Hagler, Donald J. Jr.; Venkatraman, Vijay K.; +15 Authors

Neuroanatomical Assessment of Biological Maturity

Abstract

Structural MRI allows unparalleled in vivo study of the anatomy of the developing human brain. For more than two decades, MRI research has revealed many new aspects of this multifaceted maturation process, significantly augmenting scientific knowledge gathered from postmortem studies. Postnatal brain development is notably protracted and involves considerable changes in cerebral cortical, subcortical, and cerebellar structures, as well as significant architectural changes in white matter fiber tracts (see [12]). Although much work has described isolated features of neuroanatomical development, it remains a critical challenge to characterize the multidimensional nature of brain anatomy, capturing different phases of development among individuals. Capitalizing on key advances in multisite, multimodal MRI, and using cross-validated nonlinear modeling, we demonstrate that developmental brain phase can be assessed with much greater precision than has been possible using other biological measures, accounting for more than 92% of the variance in age. Further, our composite metric of morphology, diffusivity, and signal intensity shows that the average difference in phase among children of the same age is only about 1 year, revealing for the first time a latent phenotype in the human brain for which maturation timing is tightly controlled.

Country
United States
Keywords

Male, Aging, Biomedical and clinical sciences, Adolescent, Biological Psychology, 150, 610, Neuroimaging, Psychiatry and Psychology, Nervous System, Medical and Health Sciences, Nerve Fibers, Myelinated, Young Adult, Nerve Fibers, Neural Pathways, Psychology, Humans, Preschool, Child, Psychiatry, Pediatric, Cerebral Cortex, Brain Mapping, Neuroscience and Neurobiology, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Psychology and Cognitive Sciences, Neurosciences, Brain, Biological Sciences, Magnetic Resonance Imaging, Brain Disorders, Neuroanatomy, Biological sciences, Child, Preschool, Neurological, Biomedical Imaging, Myelinated, Female, Biomarkers, Developmental Biology

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
305
Top 1%
Top 1%
Top 1%
Green
hybrid