
arXiv: 1407.1682
Family studies provide an important tool for understanding etiology of diseases, with the key aim of discovering evidence of family aggregation and to determine if such aggregation can be attributed to genetic components. Heritability and concordance estimates are routinely calculated in twin studies of diseases, as a way of quantifying such genetic contribution. The endpoint in these studies are typically defined as occurrence of a disease versus death without the disease. However, a large fraction of the subjects may still be alive at the time of follow-up without having experienced the disease thus still being at risk. Ignoring this right-censoring can lead to severely biased estimates. We propose to extend the classical liability threshold model with inverse probability of censoring weighting of complete observations. This leads to a flexible way of modeling twin concordance and obtaining consistent estimates of heritability. We apply the method in simulations and to data from the population based Danish twin cohort where we describe the dependence in prostate cancer occurrence in twins.
FOS: Computer and information sciences, Cumulative incidence, Probit model, Twins, heritability, Liability-threshold, Applications of statistics to biology and medical sciences; meta analysis, Heritability, Methodology (stat.ME), polygenic model, random effects, Polygenic model, cumulative incidence, Statistics - Methodology, competing risks, Right censoring, Estimation in survival analysis and censored data, twins, Competing risks, Random effects, right censoring, liability-threshold, probit model, Computational methods for problems pertaining to statistics
FOS: Computer and information sciences, Cumulative incidence, Probit model, Twins, heritability, Liability-threshold, Applications of statistics to biology and medical sciences; meta analysis, Heritability, Methodology (stat.ME), polygenic model, random effects, Polygenic model, cumulative incidence, Statistics - Methodology, competing risks, Right censoring, Estimation in survival analysis and censored data, twins, Competing risks, Random effects, right censoring, liability-threshold, probit model, Computational methods for problems pertaining to statistics
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