Abstract Normal practice in a compressor station with compressors in parallel is to allocate the mass flows equally. However, this strategy is not optimal if the compressors are not identical. A common reason why compressors become non-identical is because their performance degrades over time. Degradation increases the power necessary to run the compressor station and changes the optimal allocation of mass flows. This paper presents a framework for optimal operation in a compressor station with degrading compressors. The optimisation framework proposed in this work explicitly includes a model of degradation in the optimisation problem and analyses how the optimal load-sharing changes when the compressors are degrading. The optimisation framework was applied in an industrial case study of a compressor station in which three parallel compressors are subject to degradation. The case study confirms that it is possible to minimise the extra power consumption due to degradation by adjusting the operating conditions of the compressor station. The analysis also gives insights into the impact of degradation on the optimal solution when compressors work at their limits.